A way of diagnostics of osteoporosis and of determining of efficiency of preparations in treatment of this disease
Osteoporosis is considered as the most dangerous human diseases, such as oncology, myocardium infarction, and stroke. For its diagnostics and determination of therapeutic activity of various preparations may be used numerous research methods, laboratory, hystological, X-ray methods, in particular, research of biochemical markers of bone metabolism — osteocalcin, parathyroid hormone (PTH), 25(ОН) D, Beta-Cross Laps of blood serum, etc. Determinations of the last ones is not always suitable for control of effectiveness of osteoporosis therapy, especially, when osteoporosis is developing on the background of rheumatoid arthritis, multiple myeloma, etc. Histomorphological analysis of bioptat of iliac crest is regarded as the most reliable parameter in diagnostics of osteoporosis. However, invasive character of this method limits its use. The most accessible method in diagnostics of osteoporosis is a common roentgenogram. But it relates to the late diagnostics since it allows to diagnose osteoporosis only after the loss of bony tissue is more than 30-40%. It is little sufficient for evaluation of therapy. So, the most precise and informative method of determining of bone mineral density (BMD) in vivo in various parts of human skeleton with the aim of diagnostics of osteoporosis and evaluation of effectiveness of therapy is X-ray absorptiometry.