V.I. Strukov, D.G. Elistratov, A.I. Kislov, N.V. Erjomina, O.A. Ismailova, Yu.G. Shtscherbakova, T.A. Kuptsova
State educative establishment of supplementary professional education «Penza institute of physicians’ advanced training» of Health Ministry of Russia (rector – Medicine Dr., Prof. Kislov A.I.), Osteoporosis research center, Russia, Penza city. Parapharm Ltd.Co, Russia, Penza city.
Osteoporosis is reported to be one of the most serious diseases, that affects mostly the elderly men and women, sometimes with lethal effect . The mechanism of development of osteoporosis among the elderly as a result of sex hormones deficiency effect on the osseous tissue is extremely complicated and not fully researched. The blood serum of the healthy menstruating women contains estrogens as well as androgens. But when the important physiological significance of androgens in a man’s organism reproductive development is clear, the precise role of the same androgens in a woman’s organism is less investigated. Despite the fact, that the level of androgens in a woman’s organism 10-20 times lower, than in a man’s one, these hormones play significant role in woman’s organism [2,3]. Androgens have such necessary functions, as synthesis of estrogens, development of follicles, regulates the normal functioning of ovaries, osseous metabolism and sexual behavior [4,5,6]. Androgenic deficiency among women may have a negative effect on all their organs and systems. In a woman organism, androgens as well estrogens regulate the skeleton homeostasis, although relative role of each hormone is not precisely revealed. For the time present was reported, that the low level of androgens was linked to the low density of osseous tissue and increased risk of fractures [7,8].
Initially, the deficiency of estrogens, which, as was reported, might initiate processes of accelerated loss of the bone mass, independently of the causes of ovaries function insufficiency, was believed the main cause of the development of postmenopausal osteoporosis. In view of all this, the hormone replacement therapy with using estrogens is extensively used for preventing of the loss of bone tissue mass among women after menopause. It decreases substantially the risk of wrist and spine fractures .